PRF COURSE. Platelet Rich Fibrin
In the field of wound healing, the PRF since its publication in 2001 (Choukroun) has raised growing interest among dental surgeons.
PRF induces accelerated healing of soft and hard tissues. (1350 publications)
The numerous protocols of use, which must obey precise rules, have been constantly improved.
However, natural healing or healing with PRF requires certain conditions and cannot take place without an adequate performance of the different biological cascades that occur in the cells.
Oxidative stress is a physio-pathological phenomenon that will inhibit the cells to perform correctly.
This oxidative stress affects both soft tissue cells and bone cells. Bone resorption is the result of bone oxidation: inhibition of osteoblasts and activation of osteoclastogenesis. It will cause bone grafts to fail. PRF cannot be really effective if the patient is in oxidative stress, even if it’s a powerful anti-oxidant.
Because we learn more from our failures than from our successes, 4 chapters of this course are dedicated to healing failures related to the oxidative stress: biological abnormalities (smoking, diabetes), soft tissue oxidative stress, bone and bone grafts oxidation.
The last chapter will introduce the Over Concept: how to prevent complications and to achieve predictable and reproducible results.
54 Questions and Answers will help you to better understand certain aspects in all areas of PRF use and oxidative stress management.